Details of project


Sl no Item Details
1 Project title Yoga Based Intervention for Opioid Dependence: Efficacy and Potential Mechanisms
2 List of investigators Dr. Hemant Bhargav

Assistant Professor of Yoga, CIMER, Department of Psychiatry, NIMHANS


Dr Rashmi A

Assistant Professor, NICY, Department of Psychiatry, NIMHANS


Dr G Venkatasubramanian

Additional Professor,

Department of Psychiatry, NIMHANS


Dr Venkata Lakshmi Narasimha

DM in Addiction Psychiatry (2nd year)

Department of Psychiatry, NIMHANS


Dr Vedamurthachar A

Yoga Therapist,

Centre for Addiction Medicine,

Department of Psychiatry, NIMHANS


Dr. Priyamvada Sharma

Sr. Scientific Officer,

Centre for Addiction Medicine,

Department of Psychiatry, NIMHANS


Dr. Rose Dawn

Associate Professor

Department of Neuroimaging and Interventional Radiology, NIMHANS


3 Funding Agency DST- SATYAM
4 Date of commencement 14-08-2018
5 Date of Completion 13-08-2021
6 Inclusion/ Exclusion criteria 1.Aged 18 to 50 years

2.Both Genders

3.Diagnosed with Opioid dependence syndrome (prescription and street Opioids) as per ICD-10

4.Patients stabilized by medications for withdrawal symptoms

5.Willingness to provide written informed consent

7 Sample size 1.H/o or current medical illness that may significantly influence CNS function or structure

2.Patients with intractable pain due to other diseases

3.Patients on prescribed opioids for pain of other medical conditions

4.General impaired intellectual functioning (Mini-Mental Status Exam, MMSE below 24)

5.Contraindication to MRI like metal implants or paramagnetic objects within the body orclaustrophobia

6.Past history of head injury

7.Concomitant severe medical conditions

8.Those with co-morbid alcohol/BZD/Cannabis/Multiple substance dependence except nicotine

9.H/o receiving specific Yoga practice for Opioid dependence in the past

10.Pregnancy or post-partum

8 Intervention/s Study group: 10supervised sessions ofyogaas add-on treatmentfollowed by home practice for 12 weeks.

Control group:Brisk walk(1-hour session daily for 10 days) followed by home practice for 12 weeks.

9 Timeline 3 Years
10 Investigations 1.Clinical Assessments

a.Mini international neuropsychiatric interview

b. Hamilton Rating Scale for Depression:

c. Hamilton rating scale for anxiety

d. DSM-5 Criteria for Diagnosis of Opioid Use Disorder

e. Brief Substance Craving Scale (BSCS)

f. Clinical Opioid withdrawal scale (COWS)

g. Visual analog scale

h. CGI-S and CGI-I

i. Quality of life questionnaire – Short Form

j. 36 Health Survey (SF-36)

k. Sexual dysfunction questionnaire

l. Fagerström Test for Nicotine Dependence

m. Sleep Rating Questionnaire

2. Biological Assessments

a. Plasma endorphin level assessments:

b. Other lab assessments

3. EEG and fMRI acquisition and analysis


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