[vc_row][vc_column][vc_column_text]Details of project

 

Sl no Item Details
1 Project title Yoga Based Intervention for Opioid Dependence: Efficacy and Potential Mechanisms
2 List of investigators Dr. Hemant Bhargav

Assistant Professor of Yoga, CIMER, Department of Psychiatry, NIMHANS

 

Dr Rashmi A

Assistant Professor, NICY, Department of Psychiatry, NIMHANS

 

Dr G Venkatasubramanian

Additional Professor,

Department of Psychiatry, NIMHANS

 

Dr Venkata Lakshmi Narasimha

DM in Addiction Psychiatry (2nd year)

Department of Psychiatry, NIMHANS

 

Dr Vedamurthachar A

Yoga Therapist,

Centre for Addiction Medicine,

Department of Psychiatry, NIMHANS

 

Dr. Priyamvada Sharma

Sr. Scientific Officer,

Centre for Addiction Medicine,

Department of Psychiatry, NIMHANS

 

Dr. Rose Dawn

Associate Professor

Department of Neuroimaging and Interventional Radiology, NIMHANS

 

3 Funding Agency DST- SATYAM
4 Date of commencement 14-08-2018
5 Date of Completion 13-08-2021
6 Inclusion/ Exclusion criteria 1.Aged 18 to 50 years

2.Both Genders

3.Diagnosed with Opioid dependence syndrome (prescription and street Opioids) as per ICD-10

4.Patients stabilized by medications for withdrawal symptoms

5.Willingness to provide written informed consent

7 Sample size 1.H/o or current medical illness that may significantly influence CNS function or structure

2.Patients with intractable pain due to other diseases

3.Patients on prescribed opioids for pain of other medical conditions

4.General impaired intellectual functioning (Mini-Mental Status Exam, MMSE below 24)

5.Contraindication to MRI like metal implants or paramagnetic objects within the body orclaustrophobia

6.Past history of head injury

7.Concomitant severe medical conditions

8.Those with co-morbid alcohol/BZD/Cannabis/Multiple substance dependence except nicotine

9.H/o receiving specific Yoga practice for Opioid dependence in the past

10.Pregnancy or post-partum

8 Intervention/s Study group: 10 supervised sessions of yoga as add-on treatment.

Control group:Brisk walk(1-hour session daily for 10 days).

9 Timeline 3 Years
10 Investigations 1.Clinical Assessments

a.Mini international neuropsychiatric interview

b. Hamilton Rating Scale for Depression:

c. Hamilton rating scale for anxiety

d. DSM-5 Criteria for Diagnosis of Opioid Use Disorder

e. Brief Substance Craving Scale (BSCS)

f. Clinical Opioid withdrawal scale (COWS)

g. Visual analog scale

h. CGI-S and CGI-I

i. Fagerström Test for Nicotine Dependence

j. Sleep Rating Questionnaire

2. Biological Assessments

a. Plasma endorphin level assessments

3. fMRI acquisition and analysis

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